The 2022 men’s U.S. Open is set to begin Aug. 29 at the Billie Jean King National Tennis Center in Flushing, N.Y., where Daniil Medvedev will look to overcome his injury-riddled first half of the year to pull off a rare repeat as U.S. Open champion. Here, we’ll take a look at the 2022 U.S. Open odds to provide you with the necessary information to bet on the event.


2022 U.S. Open Betting Odds

Three-time champion U.S. Open champion Novak Djokovic won’t be competing in 2022, and that opens the door for a handful of players to make a run at the championship. 

The most notable beneficiary might be Daniil Medvedev, who defeated Djokovic in last year’s tournament final. He’ll return to New York to defend his U.S. Open title, but the 26-year-old Russian was forced to lay low for almost two months earlier this year due to hernia surgery. Post-surgery, he’s still looking to regain the form that brought him his first major last year.

Below is a list of the 2022 U.S. Open odds per FanDuel Sportsbook.

  • Daniil Medvedev +230
  • Rafael Nadal +380
  • Carlos Alcaraz +500
  • Nick Kyrgios +1000
  • Stefanos Tsitsipas +1600
  • Janik Sinner +1800
  • Taylor Fritz +2600
  • Matteo Berrettini +2900
  • Felix Auger-Alissime +2900
  • Borna Coric +3600
  • Cameron Norrie +4000
  • Hubert Hurkacz +4500
  • Casper Ruud +6500
  • Andrey Rublev +6500
  • Pablo Carreno Busta +6500
  • Marin Cilic +6500
  • Denis Shapovalov +10000
  • Sebastian Korda +12000
  • Francis Tiafoe +13000
  • Dominic Thiem +14000
  • Jack Draper +14000
  • Roberto Bautista Agut +15000
  • Andy Murray +16000
  • Alex de Minaur +16000
  • John Isner +17000

Who Are the Favorites at the U.S. Open?

Daniil Medvedev (+230)

The aforementioned Medvedev’s odds are a bit surprising considering his recent struggles, but oddsmakers are respecting the defending champ and his hardcourt prowess. If the world No. 2 can regain his old form, he’ll deserve every bit of the respect oddsmakers are showing him. 

Rafael Nadal (+380)

The King of Clay hasn’t been too shabby on hardcourts in his career, and that includes the four U.S. Open titles under his belt. His U.S. Open odds have come all the way down from +850 since he’s already captured two Grand Slam titles this year and won’t have to go through Djokovic. 

Carlos Alcaraz (+500)

Alcaraz has been climbing the ATP rankings for over a year now, but his glorious run at the Madrid Open earlier this year officially burst his under-the-radar bubble. The up-and-comer has been one of tennis’ best in 2022 and will look to build on his already-impressive resume.


U.S. Open Overview

The 2022 U.S. Open will serve as the 142nd edition of the tournament and it will be the fourth and final Grand Slam of the year, as it has been since 1987. The tournament is played at Billie Jean King National Tennis Center, home to the famous Arthur Ashe Stadium, and boasts 22 outdoor courts in total. The 2021 purse of over $57 million was the largest package in tournament history, with champion Daniil Medvedev taking home $2.5 million. 

When and Where to Watch the U.S. Open

When: August 29 – September 11
Where: Billie Jean King National Tennis Center, Flushing, NY
How to Watch: ESPN, ESPN2, Tennis Channel
Streaming Options: ESPN+, ESPN3

U.S. Open Frequently Asked Questions

Where can I bet on the U.S. Open?

Essentially all of the major legal sportsbooks will offer 2022 U.S. Open odds, but be sure to check out which sportsbooks are available in your state. FanDuel, DraftKings and BetMGM are widely available books that offer lucrative welcome packages and sign-up deals.

Who are the Most Recent Winners at the U.S. Open?

  • 2021 – Daniil Medvedev
  • 2020 – Dominic Thiem
  • 2019 – Rafael Nadal
  • 2018 – Novak Djokovic
  • 2017 – Rafael Nadal
  • 2016 – Stan Wawrinka
  • 2015 – Novak Djokovic
  • 2014 – Marin Cilic
  • 2013 – Rafael Nadal
  • 2012 – Andy Murray
  • 2011 – Novak Djokovic
  • 2010 – Rafael Nadal

Who has the most U.S. Open Championships of all time?

In the Open Era (since 1968), Jimmy Connors, Pete Sampras and Roger Federer have won five U.S. Open championships. Only Federer won all five titles consecutively (2004-2008).

Who has the most Grand Slams of all time?

Currently, Rafael Nadal leads Novak Djokovic in all-time Grand Slam titles 22-21. Without Djokovic in this year’s U.S. Open field, Nadal is looking to extend his lead and capture his third Grand Slam victory in 2022. 

Who is the Oldest Player to Win the U.S. Open?

Ken Rosewall won the U.S. Open in 1970 at 35 years and 10 months old. A title for Rafael Nadal (36) or Roger Federer (40) would break that record, and odds-on favorite Novak Djokovic (35) would place second on the list.

How to Bet on the 2022 U.S. Open Odds

Step 1: Set up a sports betting account

Setting up a sportsbook account is a simple process, and it would be wise to do so on as many platforms as possible. All they need is some basic information, and then you’ll be ready to place your first wager in no time. It is essential to have multiple accounts to shop for the best odds and take advantage of all the free money books like to hand out to new users. 

Step 2: Deposit money into your account

Just about every sportsbook will have some version of a deposit bonus for you after you sign up. Be sure to read the fine print to ensure you’re getting the most bang for your buck upon signup.

Step 3: Make a U.S. Open bet

Check out picks from our experts and be sure to do your own research as well. Find a player whose odds you particularly like and place a wager.