The Indianapolis Colts are hitting their stride as we head into Week 12, as they came away with an impressive win over the Buffalo Bills in Week 11. Powered by the league-leading rusher Jonathan Taylor, the Colts put up 41 points against one of the stronger defenses in the league. The team is now right in the thick of the playoff picture as they head into a tough Week 12 matchup against the Buccaneers. 



Indianapolis Colts Week 12 odds

Date/Time: November 28, 1 p.m. ET
Arena: Lucas Oil Stadium
How to watch: Fox
Opening odds: Colts +1 (DraftKings Sportsbook)

Super Bowl odds update - Indianapolis Colts

The latest Super Bowl odds for the Indianapolis Colts are at +4000 at DraftKings Sportsbook. Here is a look at the odds movement:

  • Week 11: +6000
  • Week 10: +8500
  • Week 9: +6500
  • Week 8: +5000
  • Week 7: +10000
  • Week 6: +10000
  • Week 5: +10000
  • Week 4: +10000
  • Week 3: +5000
  • Week 2: +4000
  • Week 1: +3000
  • Post-NFL Draft: +2500

Colts futures odds

The Colts are now +900 to win the AFC South at DraftKings Sportsbook. A week ago they were at +2500, and the Titans’ loss to the Texans may have opened the door for the Colts to come back and win the division. 

Jonathan Taylor is now -400 to lead the league in rushing yards at FanDuel Sportsbook. Last week he was at +110, but his dominant Week 11 performance has left him as the clear favorite.

Check out the FTNBets Prop Shop to find the best lines.

Jonathan Taylor NFL MVP odds

After his offensive explosion in Week 11, Taylor is now +2500 to win MVP at FanDuel Sportsbook. While a running back hasn’t won the award since LaDainian Tomlinson in 2006, Taylor’s offensive output gives him a chance to win the award.

Colts odds to win AFC South

The Colts are now at +900 to win the AFC South at DraftKings Sportsbook after an impressive Week 11 victory.

Indianapolis Colts betting trends

The Colts are now 8-3 against the spread. Here is how they’ve been trending since the beginning of last season:

  • 8-3 ATS in 2021
  • 8-8 ATS in 2020

Indianapolis Colts best bets - NFL Week 12

How to Bet This Game

If you want to bet on this matchup and don’t already have a sportsbook account setup, check out FTNBets’ top sportsbook page. You can see what shops are available in your state while also comparing lines, odds, promotions and bonuses to ensure you get the best value for your investment.