| QB | RB | RZB | 3RB | WR 1 | WR 2 | WR 3 | TE | K |
| Patrick Mahomes | Darrel Williams | Darrel Williams | Le'Veon Bell | Tyreek Hill | Sammy Watkins | Mecole Hardman | Travis Kelce | Harrison Butker |
| Chad Henne | Le'Veon Bell | Le'Veon Bell | Darwin Thompson | Byron Pringle | Demarcus Robinson | Andre Baccellia | Deon Yelder | - |
| - | Darwin Thompson | Clyde Edwards-Helaire | Clyde Edwards-Helaire | Jackson Barton | - | - | Ricky Seals-Jones | - |
| - | Clyde Edwards-Helaire | - | - | - | - | - | Nick Keizer | - |
Projection
| Player | Rush Yards | TDs | PPR |
| Edwards-Helaire | 940.91 | 9.1 | 269.9 |
ADP Data
| Site | Best Ball | Season Long |
 | 18.78 | 18.78 |
 | N/A | 19.10 |
 | 5.00 | 5.24 |
 | N/A | 15.40 |
